Mode of transmisison: skin-skin; including with condoms; doesn’t require penetrative intercourse

links to cancer; high risk HPV = 16,18

Incubation:

Period of infectivity:

Vaccines:

  • HPV4 = gardasil = recombinant subunit vaccine; 16,18,6,11

Schedule:

  • girls and young women aged \<20
  • 26yo with HIV
  • transplant

efficacy: significantly reduced

Herd: some herd immunity reported

  • cervical cancer

    • rapid clearance of HPV in first 6-12mo

      • 80-90% clearance by 2yrs

        • small fractuion progress to CIN2+
    • HPV 16 responsible for 60%

    • HPV 18 = 10%